Lytic gammaherpesvirus infection restricts host gene expression by promoting widespread degradation of cytoplasmic mRNA through the activity of the viral endonuclease SOX.Though generally assumed to be selective for cellular transcripts, the extent to which SOX impacts viral mRNA stability has remained unknown.We addressed this issue using the mode
Hedgehog signaling is required for many aspects of development in vertebrates and invertebrates.Misregulation of the Hedgehog pathway causes developmental abnormalities and has been implicated in certain types of cancer.Large-scale genetic screens in zebrafish have identified a group of mutations, termed you-class mutations, that share common defec
The objective of this research is to determine the extent and current characteristics of risk disclosure in Europe in the context of corporate non-financial reporting practices.A multivariate linear regression analysis on risk disclosure behaviour is performed on a sample of companies included in the EURO STOXX 50 Index, whose data were collected f
Abstract Background Actin is required for the gene expression and morphogenesis of respiratory syncytial virus (RSV), a clinically important Pneumovirus of the Paramyxoviridae family.In HEp-2 cells, dea eyewear RSV infection also induces actin stress fibers, which may be important in the immunopathology of the RSV disease.Profilin, a major regulato